10ll

Native flagellar filament from Leptospira interrogans flaB1- KO mutant strain

spinqualitylabelsall models 10ll, resolution 4.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 10ll is a 142 chain structure with sequence from Leptospira interrogans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.3Å Ligands: CA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q72RA0_LEPIC Publication Abstract from PubMed Spirochaete pathogens are among the most invasive bacteria known, causing syphilis, Lyme disease, and leptospirosis. Their tissue penetration depends on periplasmic flagellar filaments that, unlike other bacterial flagella, are encased in a spirochaete-specific multi-protein sheath and deform the cell body into motile waves. How these filaments achieve the mechanical properties needed for invasive motility has remained unclear. Here we determine complete atomic structures of the Leptospira endoflagellar filament, revealing an elaborate sheath of 9 to 12 distinct asymmetrically arranged proteins. We show that the flagellin variant forming the filament core determines sheath composition, producing curvatures ranging from ~3.5 microm(-1) to ~5.6 microm(-1). The lower-curvature architecture, employed by pathogenic Leptospira interrogans, proves essential for motility in viscous environments and during infection. Thus, Leptospira achieves environment-specific motility through modular core-sheath coupling, linking atomic-scale structural plasticity to large-scale changes in swimming behaviour. Conservation of key sheath components suggests this mechanism may extend across spirochaetes. Core-sheath coupling controls flagellar curvature and motility in Leptospira.,San Martin F, Brady MR, Fule L, Nouchikian L, Rodriguez A, Duchateau M, Mondino S, Larrieux N, Wunder EA Jr, Ko AI, Rey M, Chamot-Rooke J, Duran R, Trajtenberg F, Picardeau M, Sindelar CV, Buschiazzo A Nat Commun. 2026 Jul 25;17(1):9075. doi: 10.1038/s41467-026-75995-6. PMID:42649215 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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