10zy

Yeast co-transcriptional pre-60S assembly intermediate Pwp1 RNP

spinqualitylabelsall models 10zy, resolution 2.74Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 10zy is a 7 chain structure with sequence from Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.74Å Ligands: MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RL8A_YEAST Publication Abstract from PubMed Eukaryotic ribosomal large subunit (60 S ) assembly requires an internal transcribed spacer 2 (ITS2) to license both nucleolar and nuclear pre-60 S assembly intermediates. The underlying molecular mechanisms responsible for nucleation of pre-60 S assembly, quality control, and installation of ITS2 during co-transcriptional stages remain unknown. Here we report the earliest co-transcriptional assembly intermediates of the eukaryotic 60 S subunits. Together with biochemical assays, our data reveal the architecture of co-transcriptional pre-60 S assembly initiation and progression, as well as the molecular logic of an assembly checkpoint. This study highlights an evolutionary solution by which complex RNA folding processes can be parallelized and integrated via biological AND-gating. Mechanism for the initiation of co-transcriptional pre-60 S assembly.,Piwowarczyk R, Klinge S bioRxiv [Preprint]. 2026 May 22:2026.05.22.727207. doi: , 10.64898/2026.05.22.727207. PMID:42239465 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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