12ad

Structure of mammalian Type 2 Inositol 1,4,5-trisphosphate receptors (IP3R2) in the Apo-state

spinqualitylabelsall models 12ad, resolution 3.32Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 12ad is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.32Å Ligands: PLX, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ITPR2_MOUSE Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm (PubMed:15632133, PubMed:19608738, PubMed:20189985, PubMed:22547632, PubMed:25329695). Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (PubMed:22547632). Has neither inositol 1,4,5-trisphosphate binding activity nor calcium releasing activity.

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