| Structural highlights
12ai is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Method: | Electron Microscopy, Resolution 3.64Å |
| Ligands: | ATP, CA, I3P, PLX, ZN |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
ITPR2_MOUSE Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm (PubMed:15632133, PubMed:19608738, PubMed:20189985, PubMed:22547632, PubMed:25329695). Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (PubMed:22547632).[1] [2] [3] [4] [5] Has neither inositol 1,4,5-trisphosphate binding activity nor calcium releasing activity.[6]
References
- ↑ Iwai M, Tateishi Y, Hattori M, Mizutani A, Nakamura T, Futatsugi A, Inoue T, Furuichi T, Michikawa T, Mikoshiba K. Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant. J Biol Chem. 2005 Mar 18;280(11):10305-17. doi: 10.1074/jbc.M413824200. Epub 2005 , Jan 4. PMID:15632133 doi:https://dx.doi.org/10.1074/jbc.M413824200
- ↑ Betzenhauser MJ, Fike JL, Wagner LE 2nd, Yule DI. Protein kinase A increases type-2 inositol 1,4,5-trisphosphate receptor activity by phosphorylation of serine 937. J Biol Chem. 2009 Sep 11;284(37):25116-25. doi: 10.1074/jbc.M109.010132. Epub , 2009 Jul 16. PMID:19608738 doi:https://dx.doi.org/10.1074/jbc.M109.010132
- ↑ Tovey SC, Dedos SG, Rahman T, Taylor EJ, Pantazaka E, Taylor CW. Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase. J Biol Chem. 2010 Apr 23;285(17):12979-89. doi: 10.1074/jbc.M109.096016. Epub , 2010 Feb 26. PMID:20189985 doi:https://dx.doi.org/10.1074/jbc.M109.096016
- ↑ Wagner LE 2nd, Yule DI. Differential regulation of the InsP(3) receptor type-1 and -2 single channel properties by InsP(3), Ca(2)(+) and ATP. J Physiol. 2012 Jul 15;590(14):3245-59. doi: 10.1113/jphysiol.2012.228320. Epub , 2012 Apr 30. PMID:22547632 doi:https://dx.doi.org/10.1113/jphysiol.2012.228320
- ↑ Klar J, Hisatsune C, Baig SM, Tariq M, Johansson AC, Rasool M, Malik NA, Ameur A, Sugiura K, Feuk L, Mikoshiba K, Dahl N. Abolished InsP3R2 function inhibits sweat secretion in both humans and mice. J Clin Invest. 2014 Nov;124(11):4773-80. doi: 10.1172/JCI70720. Epub 2014 Oct 20. PMID:25329695 doi:https://dx.doi.org/10.1172/JCI70720
- ↑ Iwai M, Tateishi Y, Hattori M, Mizutani A, Nakamura T, Futatsugi A, Inoue T, Furuichi T, Michikawa T, Mikoshiba K. Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant. J Biol Chem. 2005 Mar 18;280(11):10305-17. doi: 10.1074/jbc.M413824200. Epub 2005 , Jan 4. PMID:15632133 doi:https://dx.doi.org/10.1074/jbc.M413824200
|
