1evo

NMR OBSERVATION OF A NOVEL C-TETRAD

spinqualitylabelsall models 1evo Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1evo is a 4 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed We report the NMR structure of the DNA sequence d-TGGGCGGT in Na(+) solutions at neutral pH, containing a repeat sequence from SV40 viral genome. The structure is a novel quadruplex incorporating the C-tetrad formed by symmetrical pairing of four Cs via NH(2)&bond;O(2) H-bonds in a plane. The C-tetrad has a wider cavity compared to G-tetrads and stacks well over the adjacent G4-tetrad, but poorly on the G6 tetrad. The quadruplex helix is largely underwound by 8-10 degrees compared to B-DNA except at the C5-G6 step. To our knowledge this is the first report of C-tetrad formation in DNA structures, and would be of significance from the point of view of both structural diversity and specific recognition. NMR observation of a novel C-tetrad in the structure of the SV40 repeat sequence GGGCGG.,Patel PK, Bhavesh NS, Hosur RV Biochem Biophys Res Commun. 2000 Apr 21;270(3):967-71. PMID:10772934 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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