1f84

SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIID

spinqualitylabelsall models 1f84 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1f84 is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Translation of the hepatitis C virus (HCV) polyprotein is initiated at an internal ribosome entry site (IRES) element in the 5' untranslated region of HCV RNA. The HCV IRES element interacts directly with the 40S subunit, and biochemical experiments have implicated RNA elements near the AUG start codon as required for IRES-40S subunit complex formation. The data we present here show that two RNA stem loops, domains IIId and IIIe, are involved in IRES-40S subunit interaction. The structures of the two RNA domains were solved by NMR spectroscopy and reveal structural features that may explain their role in IRES function. Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function.,Lukavsky PJ, Otto GA, Lancaster AM, Sarnow P, Puglisi JD Nat Struct Biol. 2000 Dec;7(12):1105-10. PMID:11101890 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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