1gq8

Pectin methylesterase from Carrot

spinqualitylabelsall models 1gq8, resolution 1.75Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1gq8 is a 1 chain structure with sequence from Daucus carota. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.75Å Ligands: CAC, PCA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PME_DAUCA Catalyzes the deesterification of methyl-esterified D-galactosiduronic acid units in pectic compounds. It participates in modulating cell wall during fruit ripening, cell wall extension during pollen germination, and in defense mechanisms against pathogens. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Pectin is a principal component in the primary cell wall of plants. During cell development, pectin is modified by pectin methylesterases to give different properties to the cell wall. This report describes the first crystal structure of a plant pectin methylesterase. The beta-helical structure embodies a central cleft, lined by several aromatic residues, that has been deduced to be suitable for pectin binding. The active site is found at the center of this cleft where Asp157 is suggested to act as the nucleophile, Asp136 as an acid/base and Gln113/Gln135 to form an anion hole to stabilize the transition state. Crystal structure of plant pectin methylesterase.,Johansson K, El-Ahmad M, Friemann R, Jornvall H, Markovic O, Eklund H FEBS Lett. 2002 Mar 13;514(2-3):243-9. PMID:11943159 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Methylesterase 3D structures

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