1hmj

SOLUTION STRUCTURE OF RNA POLYMERASE SUBUNIT H

spinqualitylabelsall models 1hmj Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1hmj is a 1 chain structure with sequence from Methanocaldococcus jannaschii. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RPO5_METJA DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The archaeal H and eukaryotic RPB5 RNA polymerase subunits are highly homologous and are likely to play a fundamental role in transcription that extends from archaea to humans. We report the structure of subunit H, in solution, from the archaeon Methanococcus jannaschii using multidimensional nuclear magnetic resonance. The structure reveals a novel fold containing a four-stranded mixed beta sheet that is flanked on one side by three short helices. The dominant feature is beta-ribbon motif, which presents a hydrophobic, basic surface, and defines a general RNA polymerase architectural scaffold. RNA polymerase subunit H features a beta-ribbon motif within a novel fold that is present in archaea and eukaryotes.,Thiru A, Hodach M, Eloranta JJ, Kostourou V, Weinzierl RO, Matthews S J Mol Biol. 1999 Apr 9;287(4):753-60. PMID:10191143 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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