1jgk

SOLUTION STRUCTURE OF CANDOXIN

spinqualitylabelsall models 1jgk Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1jgk is a 1 chain structure with sequence from Bungarus candidus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 19 models Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function 3NO4_BUNCA Binds and inhibits muscular and neuronal nicotinic acetylcholine receptors (nAChR). Is a reversible antagonist of muscle nAChR (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) (IC(50)=10 nM) and a potent and poorly reversible antagonist of the neuronal alpha-7/CHRNA7 nAChR (IC(50)=50 nM). May exhibit differential affinities for the two binding sites on the muscle nAChR. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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