1k4r

Structure of Dengue Virus

Loading... Status: waiting for Mol* initialization Structural highlights 1k4r is a 3 chain structure with sequence from Chimeric Tick-borne encephalitis virus/Dengue virus 4. The July 2008 RCSB PDB Molecule of the Month feature on Dengue Virus by David Goodsell is 10.2210/rcsb_pdb/mom_2008_7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 24Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function C3V005_9FLAV Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane. Structure of dengue virus: implications for flavivirus organization, maturation, and fusion.,Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH Cell. 2002 Mar 8;108(5):717-25. PMID:11893341 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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