P35_NPVAC Functions as an inhibitor of the host RNA interference antiviral response. Inhibits the insect host cell apoptotic response initiated by the viral infection. Blocks as well the activity of members of the caspase family of proteases. Required for late and very late gene expression.[1][2][3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑da Silveira EB, Cordeiro BA, Ribeiro BM, Báo SN. In vivo apoptosis induction and reduction of infectivity by an Autographa californica multiple nucleopolyhedrovirus p35(-) recombinant in hemocytes from the velvet bean caterpillar Anticarsia gemmatalis (Hübner) (Lepidoptera: Noctuidae). Res Microbiol. 2005 Dec;156(10):1014-25. PMID:16081248 doi:10.1016/j.resmic.2005.06.001
↑Clem RJ, Fechheimer M, Miller LK. Prevention of apoptosis by a baculovirus gene during infection of insect cells. Science. 1991 Nov 29;254(5036):1388-90. PMID:1962198 doi:10.1126/science.1962198
↑Mehrabadi M, Hussain M, Matindoost L, Asgari S. The Baculovirus Antiapoptotic p35 Protein Functions as an Inhibitor of the Host RNA Interference Antiviral Response. J Virol. 2015 Aug;89(16):8182-92. PMID:26018163 doi:10.1128/JVI.00802-15
