1q7l

Zn-binding domain of the T347G mutant of human aminoacylase-I

spinqualitylabelsall models 1q7l, resolution 1.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1q7l is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.4Å Ligands: GLY, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease ACY1_HUMAN Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D) [MIM:609924. ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids. Function ACY1_HUMAN Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Aminoacylase 3D structures

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