1sjw is a 1 chain structure with sequence from Streptomyces nogalater. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
SNOAL_STRNO Involved in the biosynthesis of the aromatic polyketide antibiotic nogalamycin. Catalyzes the formation of nogalaviketone from nogalonic acid methyl ester (NAME), the last ring-closure step in the biosynthesis of nogalamycin.[1][2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Torkkell S, Kunnari T, Palmu K, Hakala J, Mäntsälä P, Ylihonko K. Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater. Antimicrob Agents Chemother. 2000 Feb;44(2):396-9. PMID:10639368 doi:10.1128/AAC.44.2.396-399.2000
↑Sultana A, Kallio P, Jansson A, Wang JS, Niemi J, Mantsala P, Schneider G. Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation. EMBO J. 2004 May 5;23(9):1911-21. Epub 2004 Apr 8. PMID:15071504 doi:10.1038/sj.emboj.7600201
