1tip

THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE

spinqualitylabelsall models 1tip, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1tip is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.2Å Ligands: F6P, NEP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function F261_RAT Synthesis and degradation of fructose 2,6-bisphosphate. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The crystal structure of the fructose-2,6-bisphosphatase domain trapped during the reaction reveal a phosphorylated His 258, and a water molecule immobilized by the product, fructose-6-phosphate. The geometry suggests that the dephosphorylation step requires prior removal of the product for an 'associative in-line' phosphoryl transfer to the catalytic water. Crystal structure of a trapped phosphoenzyme during a catalytic reaction.,Lee YH, Olson TW, Ogata CM, Levitt DG, Banaszak LJ, Lange AJ Nat Struct Biol. 1997 Aug;4(8):615-8. PMID:9253407 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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