1vty

Crystal structure of a Z-DNA fragment containing thymine/2-aminoadenine base pairs

spinqualitylabelsall models 1vty, resolution 1.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1vty is a 2 chain structure with sequence from Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.3Å Ligands: 1AP, MG, NH2 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The Z-DNA structure has been shown to form in two crystals made from self-complementary DNA hexamers d(CGTDCG) and d(CDCGTG) which contain thymine/2-aminoadenine (TD) base pairs. The latter structure has been solved and refined to 1.3 A resolution and it shows only small conformational changes due to the introduction of the TD base pairs in comparison with the structure of d(CG)3. Spectroscopic studies with these compounds demonstrate that DNA molecules containing 2-aminoadenine residues form Z-DNA slightly more easily than do those containing adenine nucleotides, but not as readily as the parent sequence containing only guanine-cytosine base pairs. Crystal structure of a Z-DNA fragment containing thymine/2-aminoadenine base pairs.,Coll M, Wang AH, van der Marel GA, van Boom JH, Rich A J Biomol Struct Dyn. 1986 Oct;4(2):157-72. doi: 10.1080/07391102.1986.10506337. PMID:3271437 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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