1x0l is a 2 chain structure with sequence from Thermus thermophilus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
HICDH_THET2 Catalyzes the NAD(+)-dependent conversion of homoisocitrate to alpha-ketoadipate. In addition, has high activity with citrate, but is inactive with 3-isopropylmalate.[1][2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Miyazaki J, Kobashi N, Nishiyama M, Yamane H. Characterization of homoisocitrate dehydrogenase involved in lysine biosynthesis of an extremely thermophilic bacterium, Thermus thermophilus HB27, and evolutionary implication of beta-decarboxylating dehydrogenase. J Biol Chem. 2003 Jan 17;278(3):1864-71. Epub 2002 Nov 8. PMID:12427751 doi:https://dx.doi.org/10.1074/jbc.M205133200
↑Suzuki Y, Asada K, Miyazaki J, Tomita T, Kuzuyama T, Nishiyama M. Enhancement of the latent 3-isopropylmalate dehydrogenase activity of promiscuous homoisocitrate dehydrogenase by directed evolution. Biochem J. 2010 Oct 11;431(3):401-10. PMID:20735360 doi:10.1042/BJ20101246
