1y39

Co-evolution of protein and RNA structures within a highly conserved ribosomal domain

spinqualitylabelsall models 1y39, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1y39 is a 4 chain structure with sequence from Escherichia coli and Geobacillus stearothermophilus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.8Å Ligands: 3CO, GOL, GTP, K, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RL11_GEOSE Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The X-ray crystal structure of a ribosomal L11-rRNA complex with chloroplast-like mutations in both protein and rRNA is presented. The global structure is almost identical to that of the wild-type (bacterial) complex, with only a small movement of the protein alpha helix away from the surface of the RNA required to accommodate the altered protein residue. In contrast, the specific hydrogen bonding pattern of the mutated residues is substantially different, and now includes a direct interaction between the protein side chain and an RNA base edge and a water-mediated contact. Comparison of the two structures allows the observations of sequence variation and relative affinities of wild-type and mutant complexes to be clearly rationalized, but reinforces the concept that there is no single simple code for protein-RNA recognition. Coevolution of protein and RNA structures within a highly conserved ribosomal domain.,Dunstan MS, Guhathakurta D, Draper DE, Conn GL Chem Biol. 2005 Feb;12(2):201-6. PMID:15734647 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Ribosomal protein L11 3D structures

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