1ycq

XENOPUS LAEVIS MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF HUMAN P53

spinqualitylabelsall models 1ycq, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1ycq is a 2 chain structure with sequence from Homo sapiens and Xenopus laevis. The July 2002 RCSB PDB Molecule of the Month feature on p53 Tumor Suppressor by David S. Goodsell is 10.2210/rcsb_pdb/mom_2002_7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.3Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MDM2_XENLA E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also MDM2 MDM2 3D structures P53 3D structures

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