Structural highlights
Function
AMGDS_ACHLA Glucosyltransferase involved in the biosynthesis of the non-bilayer-prone membrane lipid alpha-monoglucosyldiacylglycerol. This is a major component for maintaining a certain anionic lipid surface charge density, for balancing the bilayer to non-bilayer phase equilibria and for keeping a constant lipid bilayer spontaneous curvature (curvature packing stress). Catalyzes the transfer of a glucosyl residue from UDP-Glc to diacylglycerol (DAG) acceptor to form the corresponding alpha-glucosyl-DAG (1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol). It can only use UDP-Glc as sugar donor and DAG is the preferred substrate.[1] [2]
References
- ↑ Berg S, Edman M, Li L, Wikström M, Wieslander A. Sequence properties of the 1,2-diacylglycerol 3-glucosyltransferase from Acholeplasma laidlawii membranes. Recognition of a large group of lipid glycosyltransferases in eubacteria and archaea. J Biol Chem. 2001 Jun 22;276(25):22056-63. PMID:11294844 doi:10.1074/jbc.M102576200
- ↑ Karlsson OP, Dahlqvist A, Vikström S, Wieslander A. Lipid dependence and basic kinetics of the purified 1,2-diacylglycerol 3-glucosyltransferase from membranes of Acholeplasma laidlawii. J Biol Chem. 1997 Jan 10;272(2):929-36. PMID:8995384 doi:10.1074/jbc.272.2.929
