1zhu

DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3'), NMR, 10 STRUCTURES

spinqualitylabelsall models 1zhu Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1zhu is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed In certain contexts the DNA triplet GGA, when juxtaposed on opposite strands of a DNA duplex, shows the unusual property of pairing with itself in an antiparallel orientation to form the (GGA)2 motif. In this motif the central guanines do not pair but intercalate and stack between sheared G.A pairs. Similar studies with GCA triplets reveal that they do not form analogous paired (GCA)2 motifs but instead strongly promote formation of a hairpin, the structure of which is now reported here. The GCA hairpin loop consists of a single cytidine residue closed by a sheared G.A pair and this structure is discussed in the context of triplet expansions in triplet-repeat diseases. Structure of a single-cytidine hairpin loop formed by the DNA triplet GCA.,Zhu L, Chou SH, Xu J, Reid BR Nat Struct Biol. 1995 Nov;2(11):1012-7. PMID:7583654 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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