| Structural highlights
Function
GATP_ARATH Transaminase that degrades gamma-amino butyric acid (GABA) and uses pyruvate or glyoxylate as amino-group acceptor, but not 2-oxoglutarate. The pyruvate-dependent activity is reversible while the glyoxylate-dependent activity is irreversible. Cannot use beta-alanine, ornithine, acetylornithine, serine, glycine, asparagine, glutamine, glutamate, valine, leucine, isoleucine, methionine, phenylalanine, histidine, lysine, arginine, aspartate, threonine, tyrosine, tryptophan, proline, or cysteine as amino donors. Modulates steady-state GABA levels in diploid pistil cells and the haploid pollen tube. Involved in the formation of a gradient of GABA along the pollen tube path. Involved in the maintenance of the shoot apical meristem (SAM) structure and subsequent adaxial-abaxial axis-dependent development of cotyledons and leaves (PubMed:21690177).[1] [2] [3] [4] [UniProtKB:P12995]
References
- ↑ Palanivelu R, Brass L, Edlund AF, Preuss D. Pollen tube growth and guidance is regulated by POP2, an Arabidopsis gene that controls GABA levels. Cell. 2003 Jul 11;114(1):47-59. doi: 10.1016/s0092-8674(03)00479-3. PMID:12859897 doi:https://dx.doi.org/10.1016/s0092-8674(03)00479-3
- ↑ Mirabella R, Rauwerda H, Struys EA, Jakobs C, Triantaphylidès C, Haring MA, Schuurink RC. The Arabidopsis her1 mutant implicates GABA in E-2-hexenal responsiveness. Plant J. 2008 Jan;53(2):197-213. PMID:17971036 doi:10.1111/j.1365-313X.2007.03323.x
- ↑ Clark SM, Di Leo R, Dhanoa PK, Van Cauwenberghe OR, Mullen RT, Shelp BJ. Biochemical characterization, mitochondrial localization, expression, and potential functions for an Arabidopsis gamma-aminobutyrate transaminase that utilizes both pyruvate and glyoxylate. J Exp Bot. 2009;60(6):1743-57. PMID:19264755 doi:10.1093/jxb/erp044
- ↑ Toyokura K, Watanabe K, Oiwaka A, Kusano M, Tameshige T, Tatematsu K, Matsumoto N, Tsugeki R, Saito K, Okada K. Succinic semialdehyde dehydrogenase is involved in the robust patterning of Arabidopsis leaves along the adaxial-abaxial axis. Plant Cell Physiol. 2011 Aug;52(8):1340-53. PMID:21690177 doi:10.1093/pcp/pcr079
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