Structural highlights
Function
TMED9_HUMAN Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.[1] [2] [3] [4] [5]
References
- ↑ Emery G, Rojo M, Gruenberg J. Coupled transport of p24 family members. J Cell Sci. 2000 Jul;113 ( Pt 13):2507-16. PMID:10852829 doi:10.1242/jcs.113.13.2507
- ↑ Emery G, Parton RG, Rojo M, Gruenberg J. The trans-membrane protein p25 forms highly specialized domains that regulate membrane composition and dynamics. J Cell Sci. 2003 Dec 1;116(Pt 23):4821-32. PMID:14600267 doi:10.1242/jcs.00802
- ↑ Gupta V, Swarup G. Evidence for a role of transmembrane protein p25 in localization of protein tyrosine phosphatase TC48 to the ER. J Cell Sci. 2006 May 1;119(Pt 9):1703-14. PMID:16595549 doi:10.1242/jcs.02885
- ↑ Mitrovic S, Ben-Tekaya H, Koegler E, Gruenberg J, Hauri HP. The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. Mol Biol Cell. 2008 May;19(5):1976-90. PMID:18287528 doi:10.1091/mbc.e07-10-0989
- ↑ Luo R, Ha VL, Hayashi R, Randazzo PA. Arf GAP2 is positively regulated by coatomer and cargo. Cell Signal. 2009 Jul;21(7):1169-79. PMID:19296914 doi:10.1016/j.cellsig.2009.03.006
