Structural highlights
Function
ACH4_CAEEL Subunit of the non-synaptic neuronal acetylcholine receptor (AChR), which may play a role in chemotaxis towards choline. After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.[1] [2]
References
- ↑ Yassin L, Gillo B, Kahan T, Halevi S, Eshel M, Treinin M. Characterization of the deg-3/des-2 receptor: a nicotinic acetylcholine receptor that mutates to cause neuronal degeneration. Mol Cell Neurosci. 2001 Mar;17(3):589-99. doi: 10.1006/mcne.2000.0944. PMID:11273652 doi:https://dx.doi.org/10.1006/mcne.2000.0944
- ↑ Treinin M, Gillo B, Liebman L, Chalfie M. Two functionally dependent acetylcholine subunits are encoded in a single Caenorhabditis elegans operon. Proceedings of the National Academy of Sciences of the United States of America. 1998 Dec 22. doi: 10.1073/pnas.95.26.15492. PMID: 9860996.
