22tr

Cryo-EM structure of Crimean-Congo hemorrhagic fever virus RNA polymerase in complex with 5' vRNA promotor

spinqualitylabelsall models 22tr, resolution 2.75Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 22tr is a 2 chain structure with sequence from Crimean-Congo hemorrhagic fever virus strain IbAr10200. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.75Å Ligands: MN, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function L_CCHFI Displays RNA-directed RNA polymerase, deubiquitinating and deISGylase activities. RNA-dependent RNA polymerase is responsible for replication and transcription of the viral RNA genome. The deubiquitinating activity cleaves both ubiquitinated and ISGylated products and may therefore regulate ubiquitin and ISG15 dependent innate immunity.

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