Structural highlights
Function
CBDAS_CANSA Oxidoreductase involved in the biosynthesis of cannabinoids-related terpenophenolic natural products, which have pharmacological activity (PubMed:17544411, PubMed:8663284). Catalyzes the stereoselective oxidative cyclization of the monoterpene moiety in cannabigerolic acid (CBGA), producing cannabidiolate (CBDA), the major cannabioid in fiber-type Cannabis plants (PubMed:17544411, PubMed:8663284). Can also use cannabinerolic acid as substrate, but not cannabigerol or cannabinerol (PubMed:17544411, PubMed:8663284).[1] [2]
References
- ↑ Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S. Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa. FEBS Lett. 2007 Jun 26;581(16):2929-34. doi: 10.1016/j.febslet.2007.05.043. Epub , 2007 May 25. PMID:17544411 doi:https://dx.doi.org/10.1016/j.febslet.2007.05.043
- ↑ Taura F, Morimoto S, Shoyama Y. Purification and characterization of cannabidiolic-acid synthase from Cannabis sativa L.. Biochemical analysis of a novel enzyme that catalyzes the oxidocyclization of cannabigerolic acid to cannabidiolic acid. J Biol Chem. 1996 Jul 19;271(29):17411-6. doi: 10.1074/jbc.271.29.17411. PMID:8663284 doi:https://dx.doi.org/10.1074/jbc.271.29.17411
