Structural highlights
Function
JZ11A_CHIGU Inhibits voltage-gated potassium channels (Kv2.1/KCNB1 > Kv4.2/KCND2 > Kv4.1/KCND1). Also inhibits voltage-gated sodium channels of subtype Nav1.5/SCN5A (in cardiac myocytes). The toxin shifts activation towards more depolarized potentials and is suggested to bind to the extracellular S3-S4 loop of the channel. Shows no significant toxic symptoms when injected into mice and into cockroaches.[1]
References
- ↑ Liao Z, Yuan C, Deng M, Li J, Chen J, Yang Y, Hu W, Liang S. Solution structure and functional characterization of jingzhaotoxin-XI: a novel gating modifier of both potassium and sodium channels. Biochemistry. 2006 Dec 26;45(51):15591-600. PMID:17176080 doi:10.1021/bi061457+
