2dl1 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
SPART_HUMAN Autosomal recessive spastic paraplegia type 20. The disease is caused by variants affecting the gene represented in this entry.
Function
SPART_HUMAN May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964).[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Renvoisé B, Parker RL, Yang D, Bakowska JC, Hurley JH, Blackstone C. SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis. Mol Biol Cell. 2010 Oct 1;21(19):3293-303. PMID:20719964 doi:10.1091/mbc.E09-10-0879
