2etn is a 3 chain structure with sequence from Thermus aquaticus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
GFH1_THEAQ Inhibits all catalytic activities of RNA polymerase (RNAP) by partially occluding its substrate-binding site and preventing NTP binding.[1][2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Hogan BP, Hartsch T, Erie DA. Transcript cleavage by Thermus thermophilus RNA polymerase. Effects of GreA and anti-GreA factors. J Biol Chem. 2002 Jan 11;277(2):967-75. Epub 2001 Oct 17. PMID:11606592 doi:https://dx.doi.org/10.1074/jbc.M108737200
↑Lamour V, Hogan BP, Erie DA, Darst SA. Crystal structure of Thermus aquaticus Gfh1, a Gre-factor paralog that inhibits rather than stimulates transcript cleavage. J Mol Biol. 2006 Feb 10;356(1):179-88. Epub 2005 Nov 17. PMID:16337964 doi:10.1016/j.jmb.2005.10.083
