2eul is a 4 chain structure with sequence from Thermus thermophilus HB8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
GFH1_THET8 Inhibits all catalytic activities of RNA polymerase (RNAP) by partially occluding its substrate-binding site and preventing NTP binding.[1][2][3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Hogan BP, Hartsch T, Erie DA. Transcript cleavage by Thermus thermophilus RNA polymerase. Effects of GreA and anti-GreA factors. J Biol Chem. 2002 Jan 11;277(2):967-75. Epub 2001 Oct 17. PMID:11606592 doi:https://dx.doi.org/10.1074/jbc.M108737200
↑Symersky J, Perederina A, Vassylyeva MN, Svetlov V, Artsimovitch I, Vassylyev DG. Regulation through the RNA polymerase secondary channel. Structural and functional variability of the coiled-coil transcription factors. J Biol Chem. 2006 Jan 20;281(3):1309-12. Epub 2005 Nov 18. PMID:16298991 doi:10.1074/jbc.C500405200
