2go5

Structure of signal recognition particle receptor (SR) in complex with signal recognition particle (SRP) and ribosome nascent chain complex

Loading... Status: waiting for Mol* initialization Structural highlights 2go5 is a 9 chain structure with sequence from Canis sp., Homo sapiens, Mus musculus and Triticum sp.. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 7.4Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SRP19_PONAB Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of SRP54 to the SRP complex (By similarity).[UniProtKB:J9PAS6] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Signal sequences of secretory and membrane proteins are recognized by the signal recognition particle (SRP) as they emerge from the ribosome. This results in their targeting to the membrane by docking with the SRP receptor, which facilitates transfer of the ribosome to the translocon. Here, we present the 8 angstrom cryo-electron microscopy structure of a "docking complex" consisting of a SRP-bound 80S ribosome and the SRP receptor. Interaction of the SRP receptor with both SRP and the ribosome rearranged the S domain of SRP such that a ribosomal binding site for the translocon, the L23e/L35 site, became exposed, whereas Alu domain-mediated elongation arrest persisted. Signal recognition particle receptor exposes the ribosomal translocon binding site.,Halic M, Gartmann M, Schlenker O, Mielke T, Pool MR, Sinning I, Beckmann R Science. 2006 May 5;312(5774):745-7. PMID:16675701 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Ribosomal protein L31 Ribosomal protein L35 Signal recognition particle 3D structures Signal recognition particle receptor 3D structures

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