2gtl

Lumbricus Erythrocruorin at 3.5A resolution

spinqualitylabelsall models 2gtl, resolution 3.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2gtl is a 15 chain structure with sequence from Lumbricus terrestris. The March 2013 RCSB PDB Molecule of the Month feature on Erythrocruorin by David Goodsell is 10.2210/rcsb_pdb/mom_2013_3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.5Å Ligands: CA, CMO, HEM, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function GLB4_LUMTE Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Annelid erythrocruorins are highly cooperative extracellular respiratory proteins with molecular masses on the order of 3.6 million Daltons. We report here the 3.5 A crystal structure of erythrocruorin from the earthworm Lumbricus terrestris. This structure reveals details of symmetrical and quasi-symmetrical interactions that dictate the self-limited assembly of 144 hemoglobin and 36 linker subunits. The linker subunits assemble into a core complex with D(6) symmetry onto which 12 hemoglobin dodecamers bind to form the entire complex. Although the three unique linker subunits share structural similarity, their interactions with each other and the hemoglobin subunits display striking diversity. The observed diversity includes design features that have been incorporated into the linker subunits and may be critical for efficient assembly of large quantities of this complex respiratory protein. Lumbricus erythrocruorin at 3.5 A resolution: architecture of a megadalton respiratory complex.,Royer WE Jr, Sharma H, Strand K, Knapp JE, Bhyravbhatla B Structure. 2006 Jul;14(7):1167-77. PMID:16843898 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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