2i9f

Structure of the equine arterivirus nucleocapsid protein

spinqualitylabelsall models 2i9f, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2i9f is a 4 chain structure with sequence from Equine arteritis virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2Å Ligands: CL, DTT, GOL, MSE, NA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function NCAP_EAVBU Publication Abstract from PubMed Equine arteritis virus (EAV) is an enveloped positive-sense RNA virus belonging to the Arteriviridae family, which also includes the porcine pathogen PRRSV and is genetically and structurally related to the coronaviruses. EAV is an important equine pathogen that has caused significant economic losses to the horse-breeding industry and has been difficult to control. The EAV virion consists of a genome-containing nucleocapsid core made of nucleocapsid (N) protein surrounded by a lipid envelope containing several membrane proteins. Here, the crystal structure of the capsid-forming domain of the EAV N protein is presented at 2.0 A resolution. The dimeric N-protein structure is similar to the previously determined structure of the N protein from PRRSV, with most differences localized to the terminal helices and flexible loops. The N protein is organized as dimers of dimers in the crystal, which may reflect the arrangement of the protein in the viral nucleocapsid. Structure of the equine arteritis virus nucleocapsid protein reveals a dimer-dimer arrangement.,Deshpande A, Wang S, Walsh MA, Dokland T Acta Crystallogr D Biol Crystallogr. 2007 May;63(Pt 5):581-6. Epub 2007, Apr 21. PMID:17452783 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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