2jil

Crystal structure of 2nd PDZ domain of glutamate receptor interacting protein-1 (GRIP1)

spinqualitylabelsall models 2jil, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2jil is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.5Å Ligands: EDO, SCN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease GRIP1_HUMAN Fraser syndrome. The disease is caused by variants affecting the gene represented in this entry. Function GRIP1_HUMAN May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).[UniProtKB:P97879] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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