2kj3

High-resolution structure of the HET-s(218-289) prion in its amyloid form obtained by solid-state NMR

spinqualitylabelsall models 2kj3 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2kj3 is a 3 chain structure with sequence from Podospora anserina. The September 2015 RCSB PDB Molecule of the Month feature on Amyloids by David Goodsell is 10.2210/rcsb_pdb/mom_2015_9. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solid-state NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function HETS_PODAS Responsible for heterokaryon incompatibility, a process that ensures that during spontaneous, vegetative cell fusion only compatible cells from the same colony survive (non-self-recognition). Forms a prion for the non-Mendelian trait [het-s]. Interacts with het-S from incompatible cells to trigger a lethal reaction that prevents the formation of viable heterokaryons. It is unknown if the native, soluble protein has a cellular function. See Also Prion 3D structures

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