2kkr is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
ATX7_HUMAN Spinocerebellar ataxia type 7. The disease is caused by mutations affecting the gene represented in this entry.
Function
ATX7_HUMAN Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Nakamura Y, Tagawa K, Oka T, Sasabe T, Ito H, Shiwaku H, La Spada AR, Okazawa H. Ataxin-7 associates with microtubules and stabilizes the cytoskeletal network. Hum Mol Genet. 2012 Mar 1;21(5):1099-110. doi: 10.1093/hmg/ddr539. Epub 2011 Nov , 18. PMID:22100762 doi:https://dx.doi.org/10.1093/hmg/ddr539
