2l4x
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Solution Structure of apo-IscU(WT)
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Structural highlights
FunctionISCU_ECOLI A scaffold on which IscS assembles Fe-S clusters. Exists as 2 interconverting forms, a structured (S) and disordered (D) form. The D-state is the preferred substrate for IscS. Converts to the S-state when an Fe-S cluster is assembled, which helps it dissociate from IscS to transfer the Fe-S to an acceptor. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.[1] [2] References
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This page was last modified 06:53, 1 May 2024.