2lkx

NMR structure of the homeodomain of Pitx2 in complex with a TAATCC DNA binding site

spinqualitylabelsall models 2lkx Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2lkx is a 3 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1yz8. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease PITX2_HUMAN Peters anomaly;Axenfeld anomaly;Rieger anomaly;Ring dermoid of cornea;Axenfeld-Rieger syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Function PITX2_HUMAN Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity).

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