2maf

Solution structure of opa60 from n. gonorrhoeae

spinqualitylabelsall models 2maf Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2maf is a 1 chain structure with sequence from Neisseria gonorrhoeae. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function OPAH_NEIGO Implicated in a number of adherence functions. OPA proteins are implicated in pathogenesis and are subject to phase variation. Publication Abstract from PubMed The structure and dynamics of Opa proteins, which we report herein, are responsible for the receptor-mediated engulfment of Neisseria gonorrheae or Neisseria meningitidis by human cells and can offer deep understanding into the molecular recognition of pathogen-host receptor interactions. Such interactions are vital to understanding bacterial pathogenesis as well as the mechanism of foreign body entry to a human cell, which may provide insights for the development of targeted pharmaceutical delivery systems. The size and dynamics of the extracellular loops of Opa60 required a hybrid refinement approach wherein membrane and distance restraints were used to generate an initial NMR structural ensemble, which was then further refined using molecular dynamics in a DMPC bilayer. The resulting ensemble revealed that the extracellular loops, which bind host receptors, occupy compact conformations, interact with each other weakly, and are dynamic on the nanosecond time scale. We predict that this conformational sampling is critical for enabling diverse Opa loop sequences to engage a common set of receptors. Structure of the Neisserial Outer Membrane Protein Opa: Loop Flexibility Essential to Receptor Recognition and Bacterial Engulfment.,Fox DA, Larsson P, Lo RH, Kroncke BM, Kasson PM, Columbus L J Am Chem Soc. 2014 May 19. PMID:24813921 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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