2mbf

Solution structure of the forkhead domain of Brugia malayi DAF-16a

spinqualitylabelsall models 2mbf Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2mbf is a 1 chain structure with sequence from Brugia malayi. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of Brugia malayi DAF-16a, a putative ortholog of Caenorhabditis elegans DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. C. elegans DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggests that B. malayi DAF-16a is a member of the FOXO family of forkhead proteins. Proteins 2014. (c) 2014 Wiley Periodicals, Inc. The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a.,Casper SK, Schoeller SJ, Zgoba DM, Phillips AJ, Morien TJ, Chaffee GR, Sackett PC, Peterson FC, Crossgrove K, Veldkamp CT Proteins. 2014 Oct 9. doi: 10.1002/prot.24701. PMID:25297652 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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