2mgn

Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3

spinqualitylabelsall models 2mgn Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2mgn is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Ligands: PQ3 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Phen-DC3 is a highly promising compound that specifically targets G-quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure of the complex formed between Phen-DC3 and an intramolecular G-quadruplex derived from the c-myc promoter. Structural information revealed that Phen-DC3 interacts with the quadruplex through extensive pi-stacking with guanine bases of the top G-tetrad. On the basis of our structure, modifications are proposed for the development of this compound for selective targeting of a specific G-quadruplex conformation. Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3.,Chung WJ, Heddi B, Hamon F, Teulade-Fichou MP, Phan AT Angew Chem Int Ed Engl. 2014 Jan 20;53(4):999-1002. doi: 10.1002/anie.201308063. , Epub 2013 Dec 16. PMID:24356977 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Proteopedia Page Contributors and Editors (what is this?)

OCA