2mix

Structure of a novel venom peptide toxin from sample limited terebrid marine snail

spinqualitylabelsall models 2mix Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2mix is a 1 chain structure with sequence from Terebridae. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 10 models Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function T3A_TERVA Publication Abstract from PubMed Disulfide-rich peptide toxins found in the secretions of venomous organisms such as snakes, spiders, scorpions, leeches, and marine snails are highly efficient and effective tools for novel therapeutic drug development. Venom peptide toxins have been used extensively to characterize ion channels in the nervous system and platelet aggregation in haemostatic systems. A significant hurdle in characterizing disulfide-rich peptide toxins from venomous animals is obtaining significant quantities needed for sequence and structural analyses. Presented here is a strategy for the structural characterization of venom peptide toxins from sample limited (4 ng) specimens via direct mass spectrometry sequencing, chemical synthesis and NMR structure elucidation. Using this integrated approach, venom peptide Tv1 from Terebra variegata was discovered. Tv1 displays a unique fold not witnessed in prior snail neuropeptides. The novel structural features found for Tv1 suggest that the terebrid pool of peptide toxins may target different neuronal agents with varying specificities compared to previously characterized snail neuropeptides. Sample limited characterization of a novel disulfide-rich venom peptide toxin from terebrid marine snail Terebra variegata.,Anand P, Grigoryan A, Bhuiyan MH, Ueberheide B, Russell V, Quinonez J, Moy P, Chait BT, Poget SF, Holford M PLoS One. 2014 Apr 8;9(4):e94122. doi: 10.1371/journal.pone.0094122. eCollection , 2014. PMID:24713808 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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