Structural highlights
Function
AGNO_POVJC Alters the structure of the nuclear envelope by interacting with host CBX5 and disrupting CBX5 association with LBR. Involved in the perinuclear-nuclear localization of the capsid protein VP1 during virion assembly and maturation. Plays an important role in the release of progeny virions from infected cells and in viral propagation, probably by acting as a viral ionic channel in the host plasma membrane. Allows influx of extracellular calcium ions in the host cell. May contribute to viral genome transcription and translation of viral late proteins.[1] [2] [3]
References
- ↑ Okada Y, Endo S, Takahashi H, Sawa H, Umemura T, Nagashima K. Distribution and function of JCV agnoprotein. J Neurovirol. 2001 Aug;7(4):302-6. PMID:11517407
- ↑ Darbinyan A, Darbinian N, Safak M, Radhakrishnan S, Giordano A, Khalili K. Evidence for dysregulation of cell cycle by human polyomavirus, JCV, late auxiliary protein. Oncogene. 2002 Aug 15;21(36):5574-81. PMID:12165856 doi:https://dx.doi.org/10.1038/sj.onc.1205744
- ↑ Suzuki T, Orba Y, Okada Y, Sunden Y, Kimura T, Tanaka S, Nagashima K, Hall WW, Sawa H. The human polyoma JC virus agnoprotein acts as a viroporin. PLoS Pathog. 2010 Mar 12;6(3):e1000801. doi: 10.1371/journal.ppat.1000801. PMID:20300659 doi:https://dx.doi.org/10.1371/journal.ppat.1000801
