2mkw

Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins

spinqualitylabelsall models 2mkw Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2mkw is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 20 models Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q5NV88_HUMAN Publication Abstract from PubMed AL amyloidosis is the most common amyloid systemic disease and it is characterized by the deposition of immunoglobulin light chain amyloid fibers in different organs, causing organ failure. The immunoglobulin light chain germinal line 6a has been observed to over-express in AL patients, moreover, it was observed that, out of these amyloidogenic proteins, 25% present a mutation of an Arg to Gly in position 24. In vitro studies have shown that this mutation produces proteins with a higher amyloid fiber propensity. It was proposed that this difference was due, in part, to the formation of a non-canonical structural element. In order to get a more detailed understanding of the structural and dynamic properties that govern the amyloid fibers formation process, we have determined the solution structure by NMR for the two constructs, showing that the difference in amyloid fibril formation is not due to sequence or structure. Solution structure of 6aJL2 and 6aJL2-R24G amyloidogenics light chain proteins.,Maya-Martinez R, Gil-Rodriguez P, Amero C Biochem Biophys Res Commun. 2015 Jan 9;456(2):695-9. doi:, 10.1016/j.bbrc.2014.12.044. Epub 2014 Dec 16. PMID:25522882 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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