2mom

Structural insights of TM domain of LAMP-2A in DPC micelles

spinqualitylabelsall models 2mom Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2mom is a 3 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease LAMP2_HUMAN Glycogen storage disease due to LAMP-2 deficiency. The disease is caused by mutations affecting the gene represented in this entry. Function LAMP2_HUMAN Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.

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