Structural highlights
Function
MCIZ_BACSU Blocks Z-ring formation in the mother cell during sporulation by inhibiting the polymerization of FtsZ (PubMed:18284588, PubMed:23237472, PubMed:25848052). Binds to the minus end of FtsZ and functions as a filament-capping protein (PubMed:25848052). At high concentrations, is capable of both capping and sequestration of FtsZ (PubMed:25848052). Decreases the GTPase activity of FtsZ (PubMed:18284588, PubMed:23237472, PubMed:25848052).[1] [2] [3]
References
- ↑ Handler AA, Lim JE, Losick R. Peptide inhibitor of cytokinesis during sporulation in Bacillus subtilis. Mol Microbiol. 2008 May;68(3):588-99. PMID:18284588 doi:10.1111/j.1365-2958.2008.06173.x
- ↑ Ray S, Kumar A, Panda D. GTP regulates the interaction between MciZ and FtsZ: a possible role of MciZ in bacterial cell division. Biochemistry. 2013 Jan 15;52(2):392-401. PMID:23237472 doi:10.1021/bi301237m
- ↑ Bisson-Filho AW, Discola KF, Castellen P, Blasios V, Martins A, Sforca ML, Garcia W, Zeri AC, Erickson HP, Dessen A, Gueiros-Filho FJ. FtsZ filament capping by MciZ, a developmental regulator of bacterial division. Proc Natl Acad Sci U S A. 2015 Apr 6. pii: 201414242. PMID:25848052 doi:https://dx.doi.org/10.1073/pnas.1414242112
