2n9h

Glucose as a nuclease mimic in DNA

spinqualitylabelsall models 2n9h Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2n9h is a 2 chain structure with sequence from Synthetic construct. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 4JA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Noncovalent forces rule the interactions between biomolecules. Inspired by a biomolecular interaction found in aminoglycoside-RNA recognition, glucose-nucleobase pairs have been examined. Deoxyoligonucleotides with a 6-deoxyglucose insertion are able to hybridize with their complementary strand, thus exhibiting a preference for purine nucleobases. Although the resulting double helices are less stable than natural ones, they present only minor local distortions. 6-Deoxyglucose stays fully integrated in the double helix and its OH groups form two hydrogen bonds with the opposing guanine. This 6-deoxyglucose-guanine pair closely resembles a purine-pyrimidine geometry. Quantum chemical calculations indicate that glucose-purine pairs are as stable as a natural T-A pair. Glucose-Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA.,Vengut-Climent E, Gomez-Pinto I, Lucas R, Penalver P, Avino A, Fonseca Guerra C, Bickelhaupt FM, Eritja R, Gonzalez C, Morales JC Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8643-7. doi: 10.1002/anie.201603510., Epub 2016 Jun 22. PMID:27328804 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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