2nb4 | pdb_00002nb4

Solution structure of Q388A3 PDZ domain

spinqualitylabelsall models 2nb4 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2nb4 is a 1 chain structure with sequence from Trypanosoma brucei brucei TREU927. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q388A3_TRYB2 Publication Abstract from PubMed PDZ domains are abundant protein interaction modules that often recognize short amino acid motifs at the C-termini of target proteins and regulate multiple biological processes. So far, no PDZ domain in Trypanosoma brucei, an eukaryotic parasite causing sleeping sickness, has been studied. Q388A3, conserved in the related kinetoplastid parasites, is a 1634-residue protein containing a PDZ domain at its C-terminus. In this work, the solution structure of Q388A3 PDZ domain was solved by NMR spectroscopy. Q388A3 PDZ domain adopts a PDZ-like fold composed by a five-stranded beta-sheet capped by two alpha-helices, which is similar to the PDZ domains from HtrA family proteins. Meanwhile, Q388A3 PDZ domain shows some structural features quite different from HtrA PDZ domain. Solution structure of Q388A3 PDZ domain from Trypanosoma brucei.,Mei S, Dong Y, Zhang J, Zhang X, Tu X J Struct Biol. 2016 May;194(2):214-7. doi: 10.1016/j.jsb.2016.02.018. Epub 2016, Feb 22. PMID:26917351 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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