2ndn

NMR solution structure of PawS Derived Peptide 20 (PDP-20)

spinqualitylabelsall models 2ndn Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2ndn is a 1 chain structure with sequence from Zinnia haageana. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 20 models Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A0A0V2B6_9ASTR Publication Abstract from PubMed A new family of small plant peptides was recently described and found to be widespread throughout the Millereae and Heliantheae tribes of the sunflower family Asteraceae. These peptides originate from the post-translational processing of unusual seed-storage albumin genes, and have been termed PawS-derived peptides (PDPs). The prototypic family member is a 14-residue cyclic peptide with potent trypsin inhibitory activity named SunFlower Trypsin Inhibitor (SFTI-1). In this study we present the features of three new PDPs discovered in the seeds of the sunflower species Zinnia haageana by a combination of de novo transcriptomics and liquid chromatography-mass spectrometry. Two-dimensional solution NMR spectroscopy was used to elucidate their structural characteristics. All three Z. haageana peptides have well-defined folds with a head-to-tail cyclized peptide backbone and a single disulfide bond. Although two possess an anti-parallel beta-sheet structure, like SFTI-1, the Z. haageana peptide PDP-21 has a more irregular backbone structure. Despite structural similarities with SFTI-1, PDP-20 was not able to inhibit trypsin, thus the functional roles of these peptides is yet to be discovered. Defining the structural features of the small cyclic peptides found in the sunflower family will be useful for guiding the exploitation of these peptides as scaffolds for grafting and protein engineering applications. Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana).,Franke B, Jayasena AS, Fisher MF, Swedberg JE, Taylor NL, Mylne JS, Rosengren KJ Biopolymers. 2016 Nov;106(6):806-817. doi: 10.1002/bip.22901. PMID:27352920 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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