2onh

Crystal Structure of of limonene synthase with 2-fluorolinalyl diphosphate(FLPP)

spinqualitylabelsall models 2onh, resolution 2.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2onh is a 2 chain structure with sequence from Mentha spicata. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.7Å Ligands: BTB, F3P, MN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q40322_MENSP Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The crystal structure of (4S)-limonene synthase from Mentha spic ata, a metal ion-dependent monoterpene cyclase that catalyzes the coupled isomerization and cyclization of geranyl diphosphate, is reported at 2.7-A; resolution in two forms liganded to the substrate and intermediate analogs, 2-fluorogeranyl diphosphate and 2-fluorolinalyl diphosphate, respectively. The implications of these findings are described for domain interactions in the homodimer and for changes in diphosphate-metal ion coordination and substrate binding conformation in the course of the multistep reaction. Structure of limonene synthase, a simple model for terpenoid cyclase catalysis.,Hyatt DC, Youn B, Zhao Y, Santhamma B, Coates RM, Croteau RB, Kang C Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5360-5. Epub 2007 Mar 19. PMID:17372193 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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