2r6p

Fit of E protein and Fab 1A1D-2 into 24 angstrom resolution cryoEM map of Fab complexed with dengue 2 virus.

Loading... Status: waiting for Mol* initialization Structural highlights 2r6p is a 7 chain structure with sequence from Dengue virus 2 Puerto Rico/PR159-S1/1969 and Mus musculus. The July 2008 RCSB PDB Molecule of the Month feature on Dengue Virus by David Goodsell is 10.2210/rcsb_pdb/mom_2008_7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 24Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q66394_9FLAV Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS011998_004_099774] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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